Identifying HLA Class I Restricted Peptides That Induce CD8+ T Cells Against SARS-CoV-2

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Grant Award Details

Grant Type:
Discovery Research Projects
Grant Number:
DISC2COVID19-11941
Investigator(s):
Name:
Dr. Albert J Wong
Institution:
Stanford University
Type:
PI

Disease Focus:
COVID-19, Infectious Disease
Human Stem Cell Use:
Adult or Tissue Stem Cell
Award Value:
$249,999
Status:
Closed

Progress Reports

Reporting Period:
Year 1

Grant Application Details

Application Title:

Identifying HLA Class I Restricted Peptides That Induce CD8+ T Cells Against SARS-CoV-2

Public Abstract:
Research Objective

A vaccine to help prevent COVID-19

Impact

There is a clear need for a vaccine to prevent the spread of the COVID-19 coronavirus that is effective, can be rapidly produced and can be scaled for worldwide demand.

Major Proposed Activities

  • Identify structural regions of SARS-Cov-2 that can inhibit viral entry
  • Identify potential regions that can induce CD8+ T cell responses
  • Confirm which regions produce peptides that bind to human HLA Class I molecules
  • Confirm which peptides induce antibodies inhibit viral entry using hematopoietic and bronchioalveolar stem cells
  • Identify which peptides induce CD8+ T cells that lyse cells containing Spike protein from SARS-CoV-2
Statement of Benefit to California:
This research will result in a vaccine candidate that can be made part of an overall vaccine composition that will protect California citizens from contracting COVID-19, allowing its people to interact freely and resume normal activities.

Publications