Late-Stage Preclinical Study of CAR-T Memory Stem Cells Targeting PSMA (P-PSMA-101) for the Treatment of Castrate-Resistant Metastatic Prostate Cancer
Grant Award Details
Grant Type:
Grant Number:
CLIN1-10999
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$3,992,090
Status:
Closed
Progress Reports
Reporting Period:
Final Operational Milestone #3
Grant Application Details
Application Title:
Late-Stage Preclinical Study of CAR-T Memory Stem Cells Targeting PSMA (P-PSMA-101) for the Treatment of Castrate-Resistant Metastatic Prostate Cancer
Public Abstract:
Therapeutic Candidate or Device
Genetically engineered, Centyrin-based, CAR- or CARTyrin-T memory stem cells
Indication
Castrate-resistant metastatic prostate cancer
Therapeutic Mechanism
The Centyrin-based chimeric antigen receptor (CARTyrin) cells are cells that are removed from a patient's body and genetically engineered to express a receptor that binds to PSMA that is selectively found on prostate cancer cells, triggering the CARTyrin T cells to specifically kill the prostate cancer cells. Because the CARTyrin T cells are stem cell memory, they can give rise to many CAR-T effector cells and persist for long periods and kill residual PSMA+ cancer cells or recurrences.
Unmet Medical Need
Other than skin cancer, prostate cancer is the most common cancer among men in the US. In the US, 172,258 men were diagnosed in 2014. Early stage prostate cancer is often managed by surgery, radiation and/or hormone suppression, however, metastatic CRPC is eventually fatal despite current treatments
Project Objective
IND submission and clinical trial start-up
Major Proposed Activities
Genetically engineered, Centyrin-based, CAR- or CARTyrin-T memory stem cells
Indication
Castrate-resistant metastatic prostate cancer
Therapeutic Mechanism
The Centyrin-based chimeric antigen receptor (CARTyrin) cells are cells that are removed from a patient's body and genetically engineered to express a receptor that binds to PSMA that is selectively found on prostate cancer cells, triggering the CARTyrin T cells to specifically kill the prostate cancer cells. Because the CARTyrin T cells are stem cell memory, they can give rise to many CAR-T effector cells and persist for long periods and kill residual PSMA+ cancer cells or recurrences.
Unmet Medical Need
Other than skin cancer, prostate cancer is the most common cancer among men in the US. In the US, 172,258 men were diagnosed in 2014. Early stage prostate cancer is often managed by surgery, radiation and/or hormone suppression, however, metastatic CRPC is eventually fatal despite current treatments
Project Objective
IND submission and clinical trial start-up
Major Proposed Activities
- Manufacturing of P-PSMA-101 tox material for IND-enabling study
- Completion of nonclinical IND-enabling studies
- Preparation and submission of IND
Statement of Benefit to California:
Metastatic CRPC is is the most common cancer among men in the US and is eventually fatal despite current treatments. Being stem cell memory CAR-T cells, this treatment could cure or control mCRPC with low toxicity, directly benefiting patients, their relatives and friends who are citizens of California. A durable, low-toxicity, one-time treatment could also reduce costs to Californians both directly and in terms of state and federal taxes by decreasing the need for subsequent medical care