Modeling the genetic basis of psychopathology in schizophrenia and autism
Grant Award Details
Grant Type:
Grant Number:
DISC4-16377
Investigator(s):
Award Value:
$12,703,708
Status:
Pre-Active
Grant Application Details
Application Title:
Modeling the genetic basis of psychopathology in schizophrenia and autism
Public Abstract:
Research Objective
We propose to apply scalable platforms for the characterization of CNVs and genes coupled with detailed characterizations of neurodevelopment of the 4 major CNV loci in model systems and patients.
Impact
A unified understanding of how genes influence neurodevelopmental processes, circuitry & how these processes influence specific psychiatric disorders will achieve new advances in psychiatric medicine.
We propose to apply scalable platforms for the characterization of CNVs and genes coupled with detailed characterizations of neurodevelopment of the 4 major CNV loci in model systems and patients.
Impact
A unified understanding of how genes influence neurodevelopmental processes, circuitry & how these processes influence specific psychiatric disorders will achieve new advances in psychiatric medicine.
Statement of Benefit to California:
A deeper knowledge of mechanisms of neuropathology in schizophrenia and autism could advance the field of psychiatric medicine and could directly benefit paients. Another major aim of this study is to extend the key findings to underserved populations. We will specifically recruit and generate 30 new patient iPSC lines from subjects in our clinical cohort that are from underrepresented populations of African, Asian and LatinX ancestry, many of which will be from Southern California.