New Methods for the Chemical Expansion of Hematopoietic Stem and Progenitor Cells

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Grant Award Details

Grant Type:
Inception – Discovery Stage Research Projects
Grant Number:
DISC1-08737
Investigator(s):
Name:
Dionicio Siegel
Institution:
University of California, San Diego
Type:
PI

Disease Focus:
Blood Disorders
Human Stem Cell Use:
Adult or Tissue Stem Cell
Award Value:
$232,200
Status:
Closed

Progress Reports

Reporting Period:
Year 2

Grant Application Details

Application Title:

New Methods for the Chemical Expansion of Hematopoietic Stem and Progenitor Cells

Public Abstract:
Research Objective

We will develop a new agent that can increase the production of hematopoietic stem and progenitor cells and determine how the compound functions

Impact

We aim to develop a method to achieve the highest fold expansion of hematopoietic stem cells from a single unit of cord blood achieved to date increasing the supply of these clinically relevant cells

Major Proposed Activities

  • We will identify the biological target(s) of our novel compound that promotes expansion and inhibit differentiation
  • We will develop conditions using existing agents for expansion in combination with our new compound to maximize the expansion of hematopoietic stem and progenitor cells from cord blood
Statement of Benefit to California:
We aim to develop a cost effective, cryopreserved source of hematopoietic stem cells by providing an expansive source of produced through the expansion of cord blood using well defined agents. This would provide a widely available, economically adjusted product for widespread use in California and beyond.

Publications