Pro-healing biomaterial for treating lung inflammation associated with COVID-19

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Grant Award Details

Grant Type:
Discovery Research Projects
Grant Number:
DISC2COVID19-12007
Investigator(s):
Name:
Dr Karen Christman
Institution:
University of California, San Diego
Type:
PI

Disease Focus:
COVID-19, Infectious Disease, Respiratory Disorders
Human Stem Cell Use:
Adult or Tissue Stem Cell
Award Value:
$221,758
Status:
Closed

Progress Reports

Reporting Period:
Year 1 plus NCE

Grant Application Details

Application Title:

Pro-healing biomaterial for treating lung inflammation associated with COVID-19

Public Abstract:
Research Objective

Pro-healing biomaterial to treat lung inflammation and promote recovery.

Impact

COVID-19 associated acute respiratory distress syndrome

Major Proposed Activities

  • Evaluate biomaterial for ability to reduce lung inflammation in rodent model
  • Evaluate biomaterial for ability to recruit stem cells in the lung
  • Evaluate biomaterial for ability to improve lung function in rodent model
  • Evaluate biomaterial for ability to recruit human stem cells
Statement of Benefit to California:
In late-June 2020, there are more than 5,700 Californians who are currently hospitalized because of COVID-19 (tested positive or suspected) with over 1,300 confirmed COVID-19 patients in the ICU. A significant number of severe cases involve a negative inflammatory response in the lungs leading to respiratory failure. We aim to develop a new therapeutic that can treat this inflammation and promote lung healing thereby having potential benefit to thousands of Californians.