The role of WNT and BMP signaling pathways in iPSC to iTenocyte step-wise differentiation for tendon repair
Grant Award Details
Grant Type:
Grant Number:
DISC0-14350
Investigator(s):
Human Stem Cell Use:
Award Value:
$1,516,563
Status:
Active
Grant Application Details
Application Title:
The role of WNT and BMP signaling pathways in iPSC to iTenocyte step-wise differentiation for tendon repair
Public Abstract:
Research Objective
Development-inspired differentiation will enable efficient and specific generation of tenocytes that can repair tendon injury, restore dysfunctional tissue, and prevent long term effects.
Impact
This study will eliminate heterogenous differentiation of pluripotent stem cells and will results in high yield and unified tenogenic phenotype.
Major Proposed Activities
Development-inspired differentiation will enable efficient and specific generation of tenocytes that can repair tendon injury, restore dysfunctional tissue, and prevent long term effects.
Impact
This study will eliminate heterogenous differentiation of pluripotent stem cells and will results in high yield and unified tenogenic phenotype.
Major Proposed Activities
- Establish the mechanism by which Wnt signaling regulate tenocyte differentiation.
- Determine the fate of iTenocytes and their ability to regenerate rat Achilles tendon defect.
Statement of Benefit to California:
While tendon and ligament injuries affects all adults, many people belong to underserved communities that more often carry government-sponsored health insurances. Despite decades of research, there are no robust biological therapies for the tendon and ligament injuries. Cell therapy with the proposed treatment candidate may provide an efficient inexhaustible off-the-shelf cell source accessible to all.