Training Program Bridging Stem Cell Research with Clinical Applications in Regenerative Medicine
Grant Award Details
Grant Type:
Grant Number:
EDUC4-12756
Investigator(s):
Award Value:
$5,373,742
Status:
Active
Progress Reports
Reporting Period:
Year 1
Reporting Period:
Year 2
Grant Application Details
Application Title:
Training Program Bridging Stem Cell Research with Clinical Applications in Regenerative Medicine
Statement of Benefit to California:
Millions of Californians suffer from incurable diseases, ranging from arthritis to debilitating neurodegenerative diseases. The promise of stem cell research to identify cures for many of these diseases has never been greater, but significant progress requires an influx of new, talented researchers and clinicians. This program is focused on rigorous training of the next generation of stem cell researchers and clinician-scientists, who will develop and implement the cures of the future. These trainees will become the research faculty who push stem cell research forward at major California universities, as well as the entrepreneurs who start new companies to produce cell and gene therapies for patients. These trainees will continue the enormous growth of stem cell science and regenerative medicine in California, generating billions of dollars of tax revenue and bettering the lives of patients looking for new types of treatments for debilitating disease. The track record of the host institution in trainee development, as well as its well-developed research and academic programs, make it highly qualified to run the proposed training program. The novel focus of the training program in bringing basic researchers and clinicians together reflects the mission of this next phase of CIRM to translate cutting-edge stem cell research into patient therapies.
Publications
- Nat Neurosci (2022): Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy. (PubMed: 35383330)
- Cell (2021): Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. (PubMed: 33417861)
- Development (2023): Craniofacial developmental biology in the single-cell era. (PubMed: 37812056)
- Nat Commun (2021): Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses. (PubMed: 34764253)
- Nat Commun (2021): The developing mouse coronal suture at single-cell resolution. (PubMed: 34376651)
- Dev Cell (2022): EED is required for mouse primordial germ cell differentiation in the embryonic gonad. (PubMed: 35679863)
- Elife (2021): Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation. (PubMed: 33501917)
- Nat Commun (2022): Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. (PubMed: 35013168)
- NPJ Regen Med (2023): Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration. (PubMed: 37726321)
- NPJ Regen Med (2021): Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. (PubMed: 34815400)
- Nat Cell Biol (2022): Not all cortical organoids are created equal. (PubMed: 35697780)
- Circ Res (2022): Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion. (PubMed: 35701867)
- Biol Psychiatry (2023): Present and Future Modeling of Human Psychiatric Connectopathies With Brain Organoids. (PubMed: 36759258)
- Front Cell Dev Biol (2021): Regeneration of Jaw Joint Cartilage in Adult Zebrafish. (PubMed: 35127702)
- Hum Mol Genet (2023): Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors. (PubMed: 36322143)
- EMBO Rep (2021): Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. (PubMed: 34232545)
- Blood (2023): RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. (PubMed: 36947858)
- Nat Commun (2023): Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. (PubMed: 36670126)
- Am Surg (2022): Telemedicine Experience of General Surgery Trainees: Impact on Patient Care and Education. (PubMed: 34049446)
- Circ Res (2022): VE-Cadherin: A Critical Sticking Point for Lymphatic System Maintenance: Role of VE-Cadherin in Lymphatic Maintenance. (PubMed: 34995134)