Translational epigenomics: dissecting cell type-specific function of neuropsychiatric risk genes in vivo
Grant Award Details
Grant Type:
Grant Number:
DISC4-16295
Investigator(s):
Award Value:
$11,376,314
Status:
Pre-Active
Grant Application Details
Application Title:
Translational epigenomics: dissecting cell type-specific function of neuropsychiatric risk genes in vivo
Public Abstract:
Research Objective
Our objective is to enable scalable genetic screening to study how different cell types and epigenetic networks are impacted by risk genes implicated in human psychiatric disorders.
Impact
We will develop and apply state-of-the-art genomic analysis to seek mechanisms and to design and test therapeutic agents for disorder modifying solutions.
Our objective is to enable scalable genetic screening to study how different cell types and epigenetic networks are impacted by risk genes implicated in human psychiatric disorders.
Impact
We will develop and apply state-of-the-art genomic analysis to seek mechanisms and to design and test therapeutic agents for disorder modifying solutions.
Statement of Benefit to California:
Mental health disorders are one of the most common health conditions faced by Californian citizens: 1 in 6 California adults have experienced some form of mental illness, and 1 in 24 have a serious condition that makes it challenging to carry out major life activities. Our work is to approach both the basic mechanisms involved in these disorder and the therapeutic development using antisense oligos to help with these devastating conditions.