Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy

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Grant Award Details

Grant Type:
Quest – Discovery Stage Research Projects
Grant Number:
DISC2-14169
Investigator(s):
Name:
Prof. Song Li
Institution:
University of California, Los Angeles
Type:
PI

Disease Focus:
Cancer, Melanoma, Solid Tumors
Human Stem Cell Use:
Adult or Tissue Stem Cell
Award Value:
$2,267,714
Status:
Active

Grant Application Details

Application Title:

Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy

Public Abstract:
Research Objective

A vaccine booster to induce antigen-specific T memory stem cells that will help enhance the long-term immunity against cancer recurrence

Impact

Cancer recurrence presents an unmet medical need. Cancer vaccines are promising, but often lack a long-term protection. We will induce T memory stem cells (TMSCs) to boost the long-term immunity.

Major Proposed Activities

  • To Develop Micro-/nanoparticles for a Sustained Release of Small Molecule and T Cell Activation Signals to Promote the Formation of TMSCs and Tumor-Antigen-Specific DCs In Vitro
  • To Investigate the Induction of TMSCs by Injectable Cancer Vaccine Booster in Young and Aged Mice
  • To Investigate the Prevention of Cancer Recurrence in Murine Models
Statement of Benefit to California:
Cancer recurrence presents an unmet medical need. Chemotherapy and radiation therapy have side effects. Cancer vaccines are promising, but may not achieve a long-term protection, especially in the elderly. Our approach can boost the therapeutic efficacy of the cancer vaccines, and help protect the patients with a more effective and less painful therapy, which will greatly reduce the burden of the healthcare and benefit the society.

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