Micro Platform for Controlled Cardiac Myocyte Differentiation
Congestive heart failure, the inability of the heart to continue to pump effectively due to damage of its muscle cells, affects approximately 4.8 million Americans and is a leading cause…
Derivation and Characterization of Cancer Stem Cells from Human ES Cells
Cancer is the leading cause of death for people younger than 85 (1). High cancer mortality rates underscore the need for more sensitive diagnostic techniques as well as therapies that…
Identifying small molecules that stimulate the differentiation of hESCs into dopamine-producing neurons
In this application, we propose to identify small molecule compounds that can stimulate human embryonic stem cells to become dopamine-producing neurons. These neurons degenerate in Parkinson’s disease, and currently have…
Human Embryonic Stem Cell Differentiation to Trophoblast: Basic Biology and Clinical Translation to Improve Human Fertility
In addition to the important potential applications for transplantation and treatment of chronic diseases, human embryonic stem cells (hESC) are also a valuable resource to study early human development relevant…
MicroRNA Regulation of Human Embryonic Stem Cell Self-Renewal and Differentiation
A major hurdle for regenerative medicine is the safe transplantation of human embryonic stem (ES) cells or their derivatives into patients. While the unlimited growth potential of ES cells is…
Role of Glycans in Human Embryonic Stem Cell Conversion to Neural Precursor Cells
Like a thick frosting on a cake, complex sugar chains decorate every surface of every cell. Try to approach a cell, as friend or foe, and the canopy of sugars…
Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells
Heart failure is a leading cause of mortality in California and the United States. Currently, there are no “cures” for heart failure.Other life threatening forms of heart disease include dysfunction…
Regulation of Specific Chromosomal Boundary Elements by CTCF Protein Complexes in Human Embryonic Stem Cells
The genetic information contained in all human cells is arranged into distinct territories or “neighborhoods” with barriers or “fences” that protect the action in one neighborhood from spilling over into…
In vitro differentiation of hESCs into corticospinal motor neurons
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurological disease that leads to the degeneration of motor neurons in the brain and in the spinal cord. There are currently…
Discovering Potent Molecules with Human ESCs to Treat Heart Disease
This work is directly relevant to human embryonic stem cell (hESC) research because it brings new ideas about novel compounds to affect cardiomyogenesis. The work addresses an urgent need to…
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