Trophoblast differentiation of human ES cells.
Human embryonic stem (ES) cells have the potential to form any cell type, but ironically, the first cell lineage to form during development still represents a surprising challenge. The first…
Gene regulatory mechanisms that control spinal neuron differentiation from hES cells.
More than 600 disorders afflict the nervous system. Common disorders such as stroke, epilepsy, Parkinson’s disease and autism are well-known. Many other neurological disorders are rare, known only to the…
Modeling Human Embryonic Development with Human Embryonic Stem Cells
Stem cells have entered the public consciousness as “cells that can do anything” and have been hailed as a panacea in the fight against disease, aging and cancer. Unfortunately, we…
Cellular epigenetic diversity as a blueprint for defining the identity and functional potential of human embryonic stem cells
Human embryonic stem (ES) cells have the capacity to self-renew but also give rise to other cell types. How this capacity is regulated and what factors determine one fate over…
New Chemokine-Derived Therapeutics Targeting Stem Cell Migration
This proposal describes a sharply-focused, timely, and rigorous effort to develop new therapies for the treatment of injuries of the Central Nervous System (CNS). The underlying hypothesis for this proposal…
Therapeutic potential of Retinal Pigment Epithelial cell lines derived from hES cells for retinal degeneration.
Retinal degeneration represents a group of blinding diseases that are increasingly impacting the health and well being of Californians. It is estimated that by 2020, over 450,000 Californians will suffer…
Optimization of guidance response in human embryonic stem cell derived midbrain dopaminergic neurons in development and disease
A promising approach to alleviating the symptoms of Parkinson’s disease is to transplant healthy dopaminergic neurons into the brains of these patients. Due to the large number of transplant neurons…
The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells
The successful use of human embryonic stem cells (hESCs) as novel regenerative therapies for a spectrum of currently incurable diseases critically depends upon the safety of such cell transfers. hESCs…
Genetic Enhancement of the Immune Response to Melanoma via hESC-derived T cells
The overall goal of the proposed studies is to utilize human gene therapy approach using human embryonic stem cells to direct our body’s defenses to specifically attack melanoma tumor cells.…
Generation of forebrain neurons from human embryonic stem cells
The goal of this proposal is to generate forebrain neurons from human embryonic stem cells. Our general strategy is to sequentially expose ES cells to signals that lead to differentiation…
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