Program Type: Infrastructure
Stem Cell-based Disease Modeling Shared Resource Laboratory
Our Shared Resource Laboratory will expand access to stem cell-derived models to support research and educational programs with two main goals: democratize access to state-of-the-art models and technology among a diverse scientific community and catalyze innovation in regenerative medicine. This Shared Resource Laboratory will expand access to stem cell-derived models to regions of Southern California […]
Stem cell-based Parternship Resource for Investigating Human Diseases and Training (SPRINT)
Use of stem cells in human disease modeling has reached a broader scientific audience of underserved, marginalized communities. Researchers/scholars have comprehensive training in iPSC generation, genetic modification, and differentiation techniques to model human diseases successfully. The core fills a gap for the scientific community, particularly those studying underserved populations where access to resources, training, expertise, […]
Creating A Collaborative California Cell and Gene Therapy Manufacturing Network
The need for cell and gene therapy product manufacturing will be ever increasing over the next decade, and several new GMP facilities are coming online. We believe it is important to continue to advance the processes and to share our accumulated knowledge for early and late-stage clinical trials. Through the proposal a partnership with other […]
Enhancing California’s Manufacturing of Leading-Edge Cell & Gene Therapies
We will implement a new staffing model, training regimen, electronic quality management system, and outreach activities to overcome current bottlenecks and provide the foundation for manufacturing the pipeline of cell and gene therapies under development to bring treatments and cures to patients. This project tackles current bottlenecks in manufacturing for cell and gene therapies and […]
Scalable Expansion for Stem Cell-derived Therapies
Succesful completion of this proposal will identify a scalable process that supports iPSC expansion, T cell expansion, and cardiomyocyte maturation / expansion that is ready for validation in a large scale bioreactor (25 – 2000L) and tech transfer to GMP manufacturing. Creating low cost scalable allogeneic therapies democratizes cell and gene therapy modalities, allowing for […]
Open Manufacturing Network for Cell and Gene Therapies
This project will establish an open-source network to share new cellular engineering platforms across manufacturing facilities; expand our non-viral engineering approaches to improve product safety and efficacy; and formalize our GMP training programs for students, staff, and leadership positions. This project will implement new non-viral engineering platforms to improve cell therapy safety and efficacy, and […]
Advancing Cell Therapy Manufacturing Through Collaboration
The project aims to provide tools & strategies to improve cell therapy manufacturing through collaborations, increase availability of viral vectors, train & educate underrepresented students, standardize data collection in academic GMP facilities, reduce costs and increase accessibility. Our proposal is driven by a deep passion for improving the lives of Californians and advancing the field […]
Laboratory for Cell and Gene Medicine: A partner in the California Cell and Gene Therapy Manufacturing Network
The Stanford LCGM supports process development and manufacturing for investigator initiated and select industry partner clinical trials. The objective of our proposal is to complete our project plan and enhance the LCGM value proposition positioning us competitively for the phase two funding period. A major roadblock in stem cell therapies is confirming efficacy in patients. […]
A comprehensive biomanufacturing center solving bottlenecks in cell and gene therapy manufacturing to accelerate new therapies for California patients
We aim to considerably expand access for all Californians to outstanding cell and gene therapy treatments for multiple patients. With operational enhancements to develop diverse talent from underserved communities, our GMP facility will advance all aspects of biomanufacturing within the network. As part of the Cell and Gene Therapy (CGT) Manufacturing Network, we will bring […]
The UCI GMP Cell and Gene Therapy Manufacturing Facility
To contribute to a network that will de-risk pathways to commercialization for cell and gene therapies and develop a diverse and skilled manufacturing workforce in California, we propose to develop and implement several key activities to meet these goals over the two years of this project proposal. This project will have a significant public impact […]