Development of novel synNotch CART cell therapy in patients with recurrent EGFRvIII+ glioblastoma

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Translational Candidate Human T cells transduced with a lentiviral vector encoding anti-EGFRvIII synNotch-primed anti-EphA2/IL-13Rα2 chimeric antigen receptor. Area of Impact Glioblastoma is the most common malignant brain tumor, affecting approximately…

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Human Neural Stem Cells (hNSCs) for neuroprotection in perinatal hypoxic-ischemic brain injury (HII)-Pre-IND-enabling Studies

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Translational Candidate An established stable human neural stem cell line unmanipulated genetically & propagated under defined conditions Area of Impact Perinatal asphyxia (also called hypoxic-ischemic injury), a major untreatable cause…

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Development of a human stem cell-derived inhibitory neuron therapeutic for the treatment of chronic focal epilepsy

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Translational Candidate A cellular therapeutic comprised of inhibitory nerve cells produced from human stem cells Area of Impact Drug-resistant chronic temporal lobe epilepsy Mechanism of Action The product candidate is…

Continue ReadingDevelopment of a human stem cell-derived inhibitory neuron therapeutic for the treatment of chronic focal epilepsy