Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) are motor neuron diseases. Motor neurons control the voluntary muscles that are used for activities such as crawling, walking, head and…
Stroke is the leading cause of adult disability. As Californians adopt health measures that minimize stroke risk factors, such as high blood pressure and smoking, the number one risk factor…
Five million people in the U.S. suffer with heart failure, resulting in ~60,000 deaths/year at a cost of $30 billion/year. Heart failure occurs when the heart is damaged and becomes…
Arthritis is a disabling condition that afflicts 6 million Californians, costing our state nearly $32 billion annually for health care and lost wages. Given the growth of an aging population…
Chronic skin wounds affect a large number of patients every year who suffer from diabetes, burns, venous disease leg ulcers, arterial disease leg ulcers, pressure ulcers, and ulcers from spinal…
This proposal is for the establishment of a group of faculty, staff and industrial partners to develop a proposal for a Diabetes Disease Team. Diabetes is one of the most…
The Human Immunodeficiency Virus (HIV) is still a major health problem. In both developed and underdeveloped nations, millions of people are infected with this virus. HIV infects cells of the…
Critical limb ischemia (CLI) represents a significant unmet medical need without any approved medical therapies for patients who fail surgical or angioplasty procedures to restore blood flow to the lower…
One in every ten thousand people in the USA has Huntington's disease, and it impacts many more. Multiple generations within a family can inherit the disease, resulting in escalating health…
This project aims to use a powerful combined stem cell and gene therapy approach to treat patients with amyotrophic lateral sclerosis (ALS or Lou Gehrig’s Disease). ALS is a devastating…
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