Year 2

Summary of overall progress: In the four months since the mid-year report, we have continued to work as planned. Our most recent progress is outlined below.
Briefly, we have continued to work on developing human TESI from varied sources of OU, in all (childhood) age ranges and disease types, with grading of the resulting TESI. Additionally, we are working on the long-term culture of the OU as well as investigating the stem/progenitor cells that ensure growth of these OU. Last, we are working in our large animal model, and have submitted multiple revisions to our animal protocol (and await approval of same) after our initial experiments indicated parameters for optimization.