Year 3

We have collected numerous skin samples from patients with a kind of dementia that affects the frontal lobes. We have also collected samples from unaffected family members (controls). For many of these samples we have made induced pluripotent stem cells (iPS), which can give rise to any cell type. We are in the process of generating neurons and other cell types, such as cells that mediate inflammation, from these stem cells. Our hope and intention is to study these cells to learn about the mechanisms that give rise to this dementia and to be able to test potential therapies.