Research Objective Our work will reveal an essential pathway that establishes precise levels of the OCT4 transcription factor and protects stem cell identity despite genetic or environmental stress. Impact Our…
Research Objective Understanding regulators of human alveolar lung stem cell function will promote more normal lung regeneration after injury and avoid the nearly untreatable problem of advanced pulmonary fibrosis. Impact…
Research Objective This proposal will elucidate the mechanisms that identify a stem/progenitor cell population in the human placenta. Impact This proposal addresses our current knowledge gap on human placental development…
Therapeutic Candidate or Device The therapeutic candidate is COVID-19 convalescent plasma (CCP) Indication The target indication is treatment of severe COVID-19 infection Therapeutic Mechanism Neutralizing antibodies are part of the…
Research Objective The objective of the proposed studies is to determine which of our excipient components are necessary for survival and neuronal differentiation of our clinical cell candidate therapy for…
Research Objective To test of exosomes (a tiny vesicle produced by stem cells) can be used to treat brain injuries rather than having to use the entire cell. Impact Not…
Research Objective This study will use high throughput single-cell capture and next-generation sequencing technologies to resolve the composition of an emerging neuronal cell therapy product. Impact If successful, this study…
Research Objective Our primary objective is to develop novel culture conditions for pluripotent stem cells that result in easier maintenance, lower-cost distribution and enhanced quality. Impact Our method ensures easy…
Research Objective We are developing a durable patient-specific dopamine neuron replacement therapy for Parkinson's disease Impact Parkinson's disease is diagnosed when half of the dopamine (DA) neurons are lost from…
Research Objective A cell therapy product comprised of inhibitory neurons that can migrate, integrate and restore neurologic function after traumatic brain injury. Impact Traumatic brain injury Major Proposed Activities Examine…
