Development of OSSM-007, cryopreserved interferon-gamma primed allogeneic MSCs, for treatment of steroid refractory acute graft versus host disease

  • Post author:
  • Post category:

Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive…

Continue ReadingDevelopment of OSSM-007, cryopreserved interferon-gamma primed allogeneic MSCs, for treatment of steroid refractory acute graft versus host disease

Placental Mesenchymal Stem Cell Augmentation of Fetal Myelomeningocele Repair

  • Post author:
  • Post category:

Therapeutic Candidate or Device Allogeneic Placenta-derived Mesenchymal Stem Cells Seeded on Cook Biodesign® Dural Graft Extracellular Matrix (PMSC-ECM) Indication Myelomeningocele (MMC) -or Spina Bifida -diagnosed prenataly Therapeutic Mechanism Placenta-derived mesenchymal…

Continue ReadingPlacental Mesenchymal Stem Cell Augmentation of Fetal Myelomeningocele Repair

Allogenic human adipose-derived mesenchymal stem cells for the treatment of knee osteoarthritis

  • Post author:
  • Post category:

Therapeutic Candidate or Device Intra-articularly injected allogeneic culture-expanded human adipose derived mesenchymal progenitor cells Indication Knee osteoarthritis Therapeutic Mechanism Cartilage regeneration (as determined by cartilage volume increase), immunomodulatory effects Unmet…

Continue ReadingAllogenic human adipose-derived mesenchymal stem cells for the treatment of knee osteoarthritis

Stem cell-derived islet cell replacement therapy with immunosuppression for high-risk type 1 diabetes

  • Post author:
  • Post category:

Therapeutic Candidate or Device hESC-derived pancreatic progenitor cells delivered in a device that allows direct vascularization of the cell therapy Indication high-risk type 1 diabetes including "brittle" diabetes and hypoglycemia…

Continue ReadingStem cell-derived islet cell replacement therapy with immunosuppression for high-risk type 1 diabetes

Development of AB-110: genetically-modified endothelial cells plus expanded cord blood hematopoietic stem cells as a transplantation therapy

  • Post author:
  • Post category:

Therapeutic Candidate or Device CD34+ Cord-Blood Derived Hematopoietic Stem and Progenitor Cells Co-Cultured and Co-Infused with Genetically Modified Endothelial Cells Indication Life-threatening high-risk hematologic malignancies including leukemia and lymphoma Therapeutic…

Continue ReadingDevelopment of AB-110: genetically-modified endothelial cells plus expanded cord blood hematopoietic stem cells as a transplantation therapy

IND-enabling study of subretinal delivery of human neural progenitor cells for the treatment of retinitis pigmentosa

  • Post author:
  • Post category:

Therapeutic Candidate or Device human fetal cortex derived neural progenitor cells (CNS10-NPC) Indication To stabilize disease progression and maintain ocular integrity and vision for RP patients. This approach can be…

Continue ReadingIND-enabling study of subretinal delivery of human neural progenitor cells for the treatment of retinitis pigmentosa