The function of YAP in human embryonic stem cells
Embryonic stem cells have the potential to generate all tissue types that could be used for regenerative medicine, such as replacement of damaged neurons, replenish of insulin secreting beta cells,…
Maturation of Human Oocytes for SCNT and Embryonic Stem Cell Derivation
A major issue for tissue and cell therapy in regenerative medicine is the immune rejection of grafts originated from a non-compatible individual. Mature eggs contain factors essential for the re-programming…
MGE Enhancers to Select for Interneuron Precursors Produced from Human ES Cells
There are now viable experimental approaches to elucidate the genetic and molecular mechanisms that underlie severe brain disorders through the generation of stem cells, called iPS cells, from the skin…
Endothelial cells and ion channel maturation of human stem cell-derived cardiomyocytes
Cardiovascular diseases remain the major cause of death in the western world. Stem and progenitor cell-derived cardiomyocytes (SPC-CMs) hold great promise for myocardial repairs. However, most SPC-CMs displayed heterogeneous and…
Role of the microenvironment in human iPS and NSC fate and tumorigenesis
Multipotent Neural Stem Cells (NSC) can be derived from adult central nervous system (CNS) tissue, embryonic stem cells (ESC), or iPSC and provide a partially committed cell population that has…
Self-renewal and senescence in iPS cells derived from patients with a stem cell disease
The discovery of induced pluripotent stem (iPS) cell technology promises to revolutionize our understanding of human disease and to allow the development of new cellular therapies for regenerative medicine applications.…
Molecular Characterization and Functional Exploration of Nuclear Receptors in hiPSCs
Our lab is known for its discovery of the family of nuclear hormone receptors (NHRs) that use vitamins/hormones to control genes and thereby regulate embryonic development, cell growth, physiology and…
RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency
Human embryonic stem cells (hESC) have the remarkable capacity to replicate indefinitely and differentiate into virtually any cell type in the human body. Maintaining this pluripotent cell state requires the…
WNT signaling and the control of cell fate decisions in human pluripotent stem cells.
With their ability to develop into virtually all mature cell types, human pluripotent stem cells (hPSC) represent a unique and powerful research tool to study the fundamental mechanisms regulating human…
Directing migration of human stem cells with electric fields
Great progress has been made in the last decades to derive many types of human stem cells for potential therapeutic uses. However, practical clinical use is severely limited by several…
