Therapeutic Candidate or Device ECT-001 graft contains more stem and immune cells than conventional cord blood graft, leading to prompt recovery and better outcomes for patients. Indication Severe Sickle Cell…
Research Objective The objective of the proposed studies is to determine which of our excipient components are necessary for survival and neuronal differentiation of our clinical cell candidate therapy for…
Research Objective We will test a novel target to augment endogenous muscle stem cell function and restore strength systemically in sarcopenia. Impact Sarcopenia can be highly disabling and has limited…
Research Objective To test of exosomes (a tiny vesicle produced by stem cells) can be used to treat brain injuries rather than having to use the entire cell. Impact Not…
Research Objective We propose to evaluate both gene addition with viral vectors and CRISPR-based gene editing of a patient's own bone marrow stem cells as a curative therapy for autosomal…
Research Objective This study will use high throughput single-cell capture and next-generation sequencing technologies to resolve the composition of an emerging neuronal cell therapy product. Impact If successful, this study…
We propose a cellular trial operation at UCSF that will focus on childhood hereditary hematological and immunologic disorders and in anti-inflammatory lung cellular therapies. This alpha clinic operation at UCSF…
We propose a cellular trial operation at UCSF that will focus on childhood hereditary hematological and immunologic disorders and in anti-inflammatory lung cellular therapies. This alpha clinic operation at UCSF…
Research Objective This DISC2 tests a strategy to target survival and self-renewal in glioma stem cells (GSC), and will identify a therapeutic candidate for safety, dosing and efficacy testing. Impact…
Research Objective This proposal will develop a cell-based therapy that can restore vision in retinal degeneration associated blindness such as Stargardt disease and age-related macular degeneration. Impact Chemically induced method…
