Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-selected CD34+ Cells in AIDS lymphoma patients
Lentiviral vector encodes a triple combination of HIV-resistance genes and a pre-selective marker. Vector transduced CD34+ cells will safely engraft, divide and differentiate in vivo into mature myeloid and lymphoid cells.
Open label, single arm study.
Safety. Efficacy - immune reconstitution, viral load and HIV status.
This study has suspended participant recruitment.