Stroke Fact Sheet

CIRM funds many projects seeking to better understand stroke and to translate those discoveries into new therapies.

Description

In the U.S., almost 800,000 people have a stroke each year and more than 140,000 people die of their stroke. It is the leading cause of serious, long-term disability in the U.S.

Stroke occurs when a blood clot blocks a vessel in the brain and cuts off blood flow. Brain cells begin to die within minutes when they are deprived of oxygen and nutrients. A less common kind of stroke involves a burst blood vessel that bleeds into the brain, also killing brain cells. Losing these brain cells can cause permanent problems with movement and cognitive abilities such as memory, attention span even speaking or understanding speech.

A stroke requires immediate treatment. Signs of stroke include sudden onset of numbness of the face, arm or leg, confusion, blurred vision, dizziness or headache. Doctors can intervene by dissolving the clot and restoring blood flow or stopping the bleeding.

After a stroke, intensive physical therapy can help people regain some lost function. However, there is currently no therapy to restore the brain cells that have died as a result of the stroke.

Stem cell scientists are attempting to use different types of stem cells including tissue-specific neural stem cells, embryonic stem cells and reprogrammed iPS cells to replace cells lost during a stroke. They are testing the different cell types in animal models of stroke to see which are best able to restore movement. They also need to learn the best way of delivering those cells into the brain. Around the country, several clinical trials are underway testing different type of cells and different delivery methods. Other researchers are seeing if it’s possible to activate the stem cells in the brain to repair the damage.

CIRM Grants Targeting Stroke

Researcher name Institution Grant Title Grant Type Approved funds
Brian Rutt Stanford University Development of Single Cell MRI Technology using Genetically-Encoded Iron-Based Reporters Tools and Technologies II $1,833,348
Stuart Lipton Sanford-Burnham Medical Research Institute Programming Human ESC-derived Neural Stem Cells with MEF2C for Transplantation in Stroke Early Translational IV $1,020,815
Gary Steinberg Stanford University Paracrine and synaptic mechanisms underlying neural stem cell-mediated stroke recovery Basic Biology V $1,178,370
Stuart Lipton The Scintillon Institute Programming Human ESC-derived Neural Stem Cells with MEF2C for Transplantation in Stroke Early Translational IV $1,103,185
Stanley Carmichael University of California, Los Angeles iPS-Interneuron Transplantation for Neural Repair after Stroke Inception - Discovery Stage Research Projects $229,396
Gary Steinberg Stanford University Intraparenchymal NR1 Stem Cell Therapy for Chronic Subcortical Ischemic Stroke Late Stage Preclinical Projects $5,300,000
Damien Bates SanBio, Inc. A Double-Blind, Controlled Ph 2b Study of the Safety and Efficacy of Modified Stem Cells in Patients with Chronic Motor Deficit from Ischemic Stroke Clinical Trial Stage Projects $19,998,580
Gary Steinberg Stanford University Embryonic-Derived Neural Stem Cells for Treatment of Motor Sequelae following Sub-cortical Stroke Disease Team Research I $17,244,851
Ziwei Huang Sanford-Burnham Medical Research Institute New Chemokine-Derived Therapeutics Targeting Stem Cell Migration SEED Grant $708,000
Yadong Huang Gladstone Institutes Defining the Isoform-Specific Effects of Apolipoprotein E on the Development of iPS Cells into Functional Neurons in Vitro and in Vivo New Faculty II $2,757,303
Stuart Lipton Sanford-Burnham Medical Research Institute MEF2C-Directed Neurogenesis From Human Embryonic Stem Cells Comprehensive Grant $2,832,000
Samuel Pleasure University of California, San Francisco Human stem cell derived oligodendrocytes for treatment of stroke and MS Comprehensive Grant $2,459,235
Guoping Fan University of California, Los Angeles Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair Comprehensive Grant $2,412,995
Stanley Carmichael University of California, Los Angeles Development of a Hydrogel Matrix for Stem Cell Growth and Neural Repair after Stroke Tools and Technologies II $1,825,613
Total:
$60,903,691.00

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