University of California, San Diego

Total Awards: 
71
Approved funds: 
$146,020,860
Institution type: 
Not for profit

Awards to the Institution

Funding
Early Translational III: Eric Adler Identification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease $1,701,575
Basic Biology V: Miles Wilkinson New Regulators of Spermatogonial Stem Cells: RHOX Homeobox Transcription Factors $619,200
Basic Biology V: Wei Wang Systems-level discovery of the regulatory mechanisms directing differentiation of hESC $1,161,000
Early Translational III: Yang Xu Human ES cell based therapy of heart failure without allogenic immune rejection $1,857,600
Basic Biology V: Maike Sander Defining links between chromatin state and developmental competence $1,161,000
Basic Biology II: Dong-Er Zhang RUNX1 in maintenance, expansion, and differentiation of therapeutic pluripotent stem cells $1,371,540
Basic Biology II: Kun-Liang Guan The function of YAP in human embryonic stem cells $1,340,565
Early Translational I: Yang Xu Developing induced pluripotent stem cells into human therapeutics and disease models $5,165,028
Basic Biology IV: Maike Sander Deciphering transcriptional control of pancreatic beta-cell maturation in vitro $1,391,400
Basic Biology IV: Miles Wilkinson Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State $1,360,450
Basic Biology IV: Ananda Goldrath Mechanisms to protect hESC-derived cells from allogenic immune rejection $1,161,000
Basic Biology IV: Eugene Yeo Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration $1,393,200
Basic Biology IV: George Sen Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases. $1,080,000
Basic Biology IV: David Traver DECIPHERING THE INSTRUCTIONS FOR VERTEBRATE HSC SPECIFICATION AND AMPLIFICATION. $1,363,698
Early Translational II: Catriona Jamieson Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy $3,341,758
Early Translational II: Alysson Muotri Developing a drug-screening system for Autism Spectrum Disorders using human neurons $1,491,471
Comprehensive Grant: Yang Xu Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells $2,570,000
Comprehensive Grant: Lawrence Goldstein Using Human Embryonic Stem Cells to Understand and to Develop New Therapies for Alzheimer's Disease $2,512,664
Comprehensive Grant: Martin Marsala Spinal ischemic paraplegia: modulation by human embryonic stem cell implant $2,445,716
New Faculty I: David Traver Genetic dissection of mesodermal commitment to the hematopoietic fates. $2,185,369
Tools and Technologies I: Ying Liu Generation of disease models for neurodegenerative disorders in hESCs by gene targeting $869,262
Training Grant I-1: Lawrence Goldstein Interdisciplinary Stem Cell Training Program at UCSD $3,683,349
Early Translational IV: Alysson Muotri A drug-screening platform for autism spectrum disorders using human astrocytes $1,824,719
SEED Grant: Sylvia Evans Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells $609,999
Transplantation Immunology: Martin Marsala Induction of immune tolerance after spinal grafting of human ES-derived neural precursors $1,387,800
Early Translational III: Eugene Yeo Molecules to Correct Aberrant RNA Signature in Human Diseased Neurons $1,654,830
Early Translational from Disease Team Conversion: Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $4,139,754
SEED Grant: Binhai Zheng Genetic manipulation of human embryonic stem cells and its application in studying CNS development and repair $642,361
Transplantation Immunology: Yang Xu Induction of immune tolerance to human embryonic stem cell-derived allografts $1,193,292
Disease Team Therapy Development III: Thomas Kipps Therapeutic Eradication of Cancer Stem Cells $4,179,600
SEED Grant: Cornelis Murre Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells $538,211
Early Translational III: Lawrence Goldstein Identifying Drugs for Alzheimer's Disease with Human Neurons Made From Human IPS cells $1,857,600
Research Leadership 12: Eric Ahrens Molecular Imaging for Stem Cell Science and Clinical Application $6,443,455
SEED Grant: Anirvan Ghosh Generation of forebrain neurons from human embryonic stem cells $612,075
Tools and Technologies II: Shu Chien Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation $1,832,515
Basic Biology V: Cornelis Murre Epigenetic mechanisms that enforce pluripotency in embryonic stem cells $1,161,000
SEED Grant: Shu Chien Combinatorial Platform for Optimizing Microenvironments to Control hESC Fate $638,140
Tools and Technologies II: Lawrence Goldstein Developing a method for rapid identification of high-quality disease specific hIPSC lines $1,816,157
Early Translational III: Mark Tuszynski Functional Neural Relay Formation by Human Neural Stem Cell Grafting in Spinal Cord Injury $4,699,569
Basic Biology V: David Cheresh CD61-driven stemness program in epithelial cancer $1,161,000
SEED Grant: Catriona Jamieson Derivation and Characterization of Cancer Stem Cells from Human ES Cells $642,500
Tools and Technologies II: Karl Willert Homologous recombination in human pluripotent stem cells using adeno-associated virus. $1,993,586
New Faculty II: Shyni Varghese A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment $2,300,569
Basic Biology III: Eugene Yeo Neural and general splicing factors control self-renewal, neural survival and differentiation $1,372,660
Basic Biology I: Karl Willert WNT signaling and the control of cell fate decisions in human pluripotent stem cells. $1,376,802
New Faculty II: Benjamin Yu Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $3,231,649
Basic Biology III: David Cheresh Molecular basis of human ES cell neurovascular differentiation and co-patterning $1,361,448
Basic Biology I: Eugene Yeo RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency $1,376,802
New Faculty II: Catriona Jamieson Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells $3,240,572
Basic Biology III: Deborah Spector Viral-host interactions affecting neural differentiation of human progenitors $1,372,660
Basic Biology V: Christian Metallo Metabolic regulation of cardiac differentiation and maturation $1,124,834
New Faculty II: Mana Parast Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal $3,253,580
Basic Biology III: Kun Zhang Functional characterization of mutational load in nuclear reprogramming and differentiation $1,382,140
Basic Biology V: Lawrence Goldstein Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes $1,161,000
Basic Biology III: Binhai Zheng Generation and characterization of corticospinal neurons from human embryonic stem cells $1,355,063
Basic Biology V: Dianne McKay Role of intracytoplasmic pattern recognition receptors in HSC engraftment $615,639
Basic Biology III: Anirvan Ghosh Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells $1,391,400
New Faculty Physician Scientist: Mana Parast Human pluripotent stem cell-based therapeutics for preeclampsia $3,188,252
Disease Team Planning: Lawrence Goldstein Human Stem Cell Approaches to Alzheimers Disease Therapies $55,000
Basic Biology III: Farah Sheikh Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC $1,341,955
Tissue Collection for Disease Modeling: Kang Zhang Generation of fibroblast cell lines in patients with common blinding eye diseases $1,034,452
Disease Team Planning: Dennis Carson CIRM Planning Grant in Leukemia $55,000
Disease Team Research I: Dennis Carson Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) $19,999,826
Shared Labs: Karl Willert Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells $3,737,696
Basic Biology III: Charles King Biological relevance of microRNAs in hESC differentiation to endocrine pancreas $1,313,649
Tissue Collection for Disease Modeling: Joseph Gleeson CIRM Tissue Collection for Neurodevelopmental Disabilities $874,135
Disease Team Research I: Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $5,694,308
Tools and Technologies I: Steve Dowdy TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells $925,200
Research Training II: Sylvia Evans Interdisciplinary Stem Cell Training Program $7,890,588
Tissue Collection for Disease Modeling: Douglas Galasko Collection of skin biopsies to prepare fibroblasts from patients with Alzheimer's disease and cognitively healthy elderly controls $643,693
New Cell Lines: Steve Dowdy Protein transduction of transcription factors: a non-genetic approach to generate new pluripotent cell lines from human skin. $1,387,800
Total:
$154,313,380.00
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© 2013 California Institute for Regenerative Medicine