Disease Focus: Bone or Cartilage Disease
IND-enabling development of ART352-L, an endogenous stem cell reactivation therapy to enhance bone healing in the elderly
Therapeutic Candidate or Device ART352-L, a liposomal formulation of recombinant human WNT3A protein that is intended to enhance the osteogenic properties of autografts in elderly Indication Patients with Degenerative Spondylolisthesis (DS) undergoing a spinal fusion surgery Therapeutic Mechanism WNT proteins are potent pro-osteogenic signals. L-WNT3A is the investigative prototype material of ART352-L. L-WNT3A treated autografts […]
Allogenic human adipose-derived mesenchymal stem cells for the treatment of knee osteoarthritis
Therapeutic Candidate or Device Intra-articularly injected allogeneic culture-expanded human adipose derived mesenchymal progenitor cells Indication Knee osteoarthritis Therapeutic Mechanism Cartilage regeneration (as determined by cartilage volume increase), immunomodulatory effects Unmet Medical Need There is no approved disease modification therapy for osteoarthritis (OA), and OA is a leading cause of both hospitalization and joint replacement surgery. […]
Development of a Chondrogenic Drug Candidate Targeting Resident Mesenchymal Stem Cells for the Treatment of Osteoarthritis
Therapeutic Candidate or Device The therapeutic candidate is a drug-like small molecule that promotes cartilage resident mesenchymal stem cell differentiation into chondrocytes. Indication Osteoarthritis and cartilage injury Therapeutic Mechanism The therapeutic candidate, through intra-articular administration, promotes cartilage resident mesenchymal stem cell differentiation into chondrocytes. The newly formed chondrocytes replace the dead chondrocytes, synthesize and secret […]
Jill Helms, Stanford – CIRM Stem Cell #SciencePitch
Edward Hsiao, UCSF – CIRM Stem Cell #SciencePitch
Songtao Shi, USC – CIRM Stem Cell #SciencePitch
Produced by the University of Southern California
Healing Bones with Stem Cells at UC Davis – Intro: CIRM Spotlight on Disease
On March 21, 2012, the CIRM board governing heard from UC Davis researchers who are using bone marrow derived mesenchymal stem cells to develop new methods for repairing bone deformities and non-healing bone fractures. A clinical trial participant who has benefited from these new methods also spoke. In this video, Claire Pomeroy, vice chancellor of […]
Healing Bones with Stem Cells at UC Davis – Kent Leach: CIRM Spotlight on Disease
The current gold standard for treating non-healing bone fractures and diseases is to graft bone from a healthy part of the body. However, in many cases this method is not sufficient, such as the failed bone grafts for movie critic Roger Ebert, who lost his lower jaw from cancer. Dr. Kent Leach, associate professor of […]
Healing Bones with Stem Cells at UC Davis – Mark Lee: CIRM Spotlight on Disease
Severe bone fractures can lead to such massive bone loss that realigning and fixing the bone with implants is not enough to heal the bone. In these cases, the trauma victim is left with chronic pain and non-functioning limbs. Dr. Mark Lee, an orthopedic surgeon at the UC Davis School of Medicine, is developing new […]
Stem Cell Clinical Trial for Broken Bones – A Patient’s Story: CIRM Spotlight on Disease
For Diane Souza, working on her 23 acre ranch in Northern California is a labor of love. But an accident in 2011 left her with a broken arm that would not heal. Souza was faced with the possibility of having only one working arm. Not wanting to give up her ranch life, she entered a […]