Disease Focus: Bone or Cartilage Disease
Stem Cell-Based Therapy for Cartilage Regeneration and Osteoarthritis
Arthritis is the result of degeneration of cartilage (the tissue lining the joints) and leads to pain and limitation of function. Arthritis and other rheumatic diseases are among the most common of all health conditions and are the number one cause of disability in the United States. The annual economic impact of arthritis in the […]
Skeletogenic Neural Crest Cells in Embryonic Development and Adult Regeneration of the Jaw
The goal of this proposal is to develop cell-based therapies that lead to the better healing of traumatic head injuries. Our first strategy will be to use genetics and embryology in zebrafish to identify factors that can convert human embryonic stem cells into replacement skeleton for the head and face. Remarkably, the genes and mechanisms […]
hESCs for Articular Cartilage Regeneration
Mobility is critical for human social interactions and quality of life. In the aged mobility is progressively impaired due to painful joints. The articular cartilage in the joints is damaged. The long-term goal of our research is the utilization of human embryonic stem cells (hESCs) for cartilage formation and therefore, regeneration of articular cartilage. Stem […]
Jill Helms, Stanford – CIRM Stem Cell #SciencePitch
Edward Hsiao, UCSF – CIRM Stem Cell #SciencePitch
Songtao Shi, USC – CIRM Stem Cell #SciencePitch
Produced by the University of Southern California
Healing Bones with Stem Cells at UC Davis – Intro: CIRM Spotlight on Disease
On March 21, 2012, the CIRM board governing heard from UC Davis researchers who are using bone marrow derived mesenchymal stem cells to develop new methods for repairing bone deformities and non-healing bone fractures. A clinical trial participant who has benefited from these new methods also spoke. In this video, Claire Pomeroy, vice chancellor of […]
Healing Bones with Stem Cells at UC Davis – Kent Leach: CIRM Spotlight on Disease
The current gold standard for treating non-healing bone fractures and diseases is to graft bone from a healthy part of the body. However, in many cases this method is not sufficient, such as the failed bone grafts for movie critic Roger Ebert, who lost his lower jaw from cancer. Dr. Kent Leach, associate professor of […]
Healing Bones with Stem Cells at UC Davis – Mark Lee: CIRM Spotlight on Disease
Severe bone fractures can lead to such massive bone loss that realigning and fixing the bone with implants is not enough to heal the bone. In these cases, the trauma victim is left with chronic pain and non-functioning limbs. Dr. Mark Lee, an orthopedic surgeon at the UC Davis School of Medicine, is developing new […]
Stem Cell Clinical Trial for Broken Bones – A Patient’s Story: CIRM Spotlight on Disease
For Diane Souza, working on her 23 acre ranch in Northern California is a labor of love. But an accident in 2011 left her with a broken arm that would not heal. Souza was faced with the possibility of having only one working arm. Not wanting to give up her ranch life, she entered a […]