Year 3

Significant progress was made in the three aims of this project. Most important was the finding that we could markedly improve engraftment of foreign hematopoietic stem cells by removing certain receptors of the innate immune system from the donor stem cells. We have pursued an understanding of how cells without these innate immune receptors can be better at engraftment. It appears that T cells lacking these receptors are less able to proliferate in response to the foreign antigens.